Canine demodicosis: Hematological and biochemical alterations

Immunology and pathogenesis of canine demodicosis.

Demodex mites colonized the hair follicles and sebaceous glands of mammals millions of years ago and have remained relatively unchanged in this protected ecologic niche since then. The host immune system detects and tolerates their presence. Toll-like receptor-2 of keratinocytes has been demonstrated to recognize mite chitin and to elicit an innate immune response. The subsequent acquired immun...

Practical and update management of canine demodicosis

Canine demodicosis is a common parasitic skin disease in dogs. It can be classified into 2 types based on distribution of lesion; localized and generalized demodicosis. Localized demodicois was reported to be usually spontaneous remission, therefore, no treatment is needed. Generalized demodicosis, on the other hand, cannot heal spontaneously so miticidal therapy should be prescribed. However, ...

Hematological alterations during experimental canine infection by Trypanosoma cruzi.

To confirm that Beagle dogs are a good experimental model for Chagas disease, we evaluated hematological alterations during the acute and chronic phases in Beagle dogs infected with the Y, Berenice-78 (Be-78) and ABC strains of Trypanosomacruzi, correlating clinical signs with the parasitemia curve. We demonstrate that the acute phase of infection was marked by lethargy and loss of appetite. Si...

What Is New about Canine Demodicosis

Fructooligosaccharide raftilose reduces the mycophenolate mofetil-induced complications: Hematological and biochemical alterations

Mycophenolate mofetil (MMF) is a selective inhibitor of Inosine-5′-monophosphate dehydrogenase. Gastrointestinal (GI) disturbances in immature ones are reported for MMF-induced compilations, which in the case of occurrence dose reduction is required. Thus, in the present study, the fructooligosaccharide raftilose® (RFT) was co-administrated with MMF to estimate the protective effect ...